2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive rats

These data demonstrate that 2-methoxyestradiol protects the vasculature from hypertension-induced myocardial arterial remodeling in male and ovarectomized SHR, and that might be in part related to decreased superoxide generation and ERK1/2 activation.