کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10747304 | 1048935 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The cell giveth and the cell taketh away: An overview of Notch pathway activation by endocytic trafficking of ligands and receptors
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کلمات کلیدی
NICDNotch extracellular domainNECDHeterodimerization domainCSLESCRTLGDLNRDSLHRSNRREGFEndocytosis - آندوسیتوز یا درون بریHepatocyte growth factor-regulated tyrosine kinase substrate - سوسپانیت تیروزین کیناز تنظیم شده توسط عامل رشد هپاتوسیتSignaling - سیگنالینگepidermal growth factor - عامل رشد اپیدرمیendosomal sorting complexes required for transport - مجتمع های مرتب سازی آندوسومی برای حمل و نقل مورد نیاز استNotch - نچReceptor - گیرنده
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The cell giveth and the cell taketh away: An overview of Notch pathway activation by endocytic trafficking of ligands and receptors The cell giveth and the cell taketh away: An overview of Notch pathway activation by endocytic trafficking of ligands and receptors](/preview/png/10747304.png)
چکیده انگلیسی
Notch signaling is firmly established as a form of cell-to-cell communication that is critical throughout development. Dysregulation of Notch has been linked to cancer and developmental disorders, making it an important target for therapeutic intervention. One aspect of this pathway that sets it apart from others is its apparent reliance on endocytosis by signal-sending and signal-receiving cells. The subtle details of endocytosis-mediated molecular processing within both ligand- and receptor-presenting cells that are required for the Notch signal to maintain fidelity remain unclear. The endosomal system has long been known to play an important role in terminating signal transduction by directing lysosomal trafficking and degradation of cell surface receptors. More recently, endocytic trafficking has also been shown to be critical for activation of signaling. This review highlights four models of endocytic processing in the context of the Notch pathway. In ligand-presenting cells, endocytosis may be required for pre-processing of ligands to make them competent for interaction with Notch receptors and/or for exerting a pulling force on the ligand/Notch complex. In receptor-presenting cells, endocytosis may be a prerequisite for Notch cleavage and thus activation and/or it could be a means of limiting ligand-independent Notch activation. Recent advances in our understanding of how and why endocytosis of Notch receptors and ligands is required for activation and termination of signaling during normal development and in disease states are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 113, Issue 3, May 2011, Pages 248-255
Journal: Acta Histochemica - Volume 113, Issue 3, May 2011, Pages 248-255
نویسندگان
Emily B. Pratt, Jill S. Wentzell, Julia E. Maxson, Lauren Courter, Dennis Hazelett, Jan L. Christian,