Cytoskeletal and scaffolding proteins as structural and functional determinants of TRP channels

► TRP channel function plays an important role in intracellular calcium homeostasis. ► The actin cytoskeleton regulates the surface expression of TRP channels. ► The cytoskeleton might act both as a modulator and a modulated downstream effector of TRP channels. ► Scaffolding proteins determine TRP localization in specialized functional microdomains.