Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells

► Paxillin tyrosine phosphorylation parallels PLD activity in MDA-MB-231 cells. ► PLD activity inhibits Erk phosphorylation in MDA-MB-231 cells ► PLD activity inhibits complex formation between Erk and paxillin in MDA-MB-231 cells. ► Supression of Erk activation allows paxillin tyrosine phosphorylation. ► FAK and paxillin complex formation depends upon PLD activity.