Glioma stem cell invasion through regulation of the interconnected ERK, integrin α6 and N-cadherin signaling pathway

► GSCs use N-cadherin and integrin α6 interactions to regulate ERK mediated invasion. ► GSC and surgical biopsies reveal the co-localization of N-cadherin and integrin α6. ► ERK knockdown reduces N-cadherin and integrin α6 co-localization in GSC. ► hUCBSC co-culture decreases N-cadherin, integrin α6 and pERK associations in GSC.