Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: Indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases

► DUSPs could influence acute EGF effects on ERK directly or indirectly. ► The DUSPs tested had no direct negative effects on ERK signalling. ► siRNAs targeting JNK/p38-specific DUSP 10 and DUSP 16 revealed indirect modulation. ► DUSPs 10 and 16 positively modulate EGF effects by reducing p38-mediated feedback. ► DUSPs are potential therapeutic targets with effects beyond preferred substrates.