BCL11B tumor suppressor inhibits HDM2 expression in a p53-dependent manner

► BCL11B tumor suppressor inhibits HMD2 expression in a p53-dependent manner. ► BCL11B associates with the HMD2 P2 promoter. ► BCL11B attenuates the p53-dependent HDM2 promoter activation after γ-irradiation. ► BCL11B may contribute to the regulation of p53-HDM2 feedback loop.