کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10817107 | 1058665 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular responses to acidosis of central chemosensitive neurons in brain
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CREOvarian cancer G-protein-coupled receptor 1OGR1Ca2+/CaMATF-2Phospholipase C-βc-Jun NH2-terminal kinaseGLUTASICinositol triphosphatePKCJnkAP-1IP3ERKVMSPLCβbZIPCa2+/calmodulin - Ca2 + / کالمدولینGlucose transporter - حمل و نقل گلوکزbasic leucine zipper - زیپ پایه لوسینVentral medullary surface - سطح مفاصل شکمیDifferential display - صفحه نمایش دیفرانسیلcyclic AMP response element - عنصر پاسخ AMP cyclicNuclear transcription factor - فاکتور رونویسی هسته ایactivating transcription factor-2 - فعال کردن عامل رونویسی 2map - نقشهGlucose homeostasis - هوموستاز گلوکزmitogen-activated protein - پروتئین فعال mitogenactivator protein 1 - پروتئین فعال کننده 1Protein kinase C - پروتئین کیناز سیCa2+ channels - کانال های Ca2 +extracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Significant advances have been made in understanding how neurons sense and respond to acidosis at the cellular level. Decrease in pH of the cerebrospinal fluid followed by hypercapnia (increased arterial CO2) is monitored by the chemosensory neurons of the medulla oblongata. Then the intracellular signalling pathways are activated to regulate specific gene expression, which leads to a hyperventilatory response. However, little is known about molecular details of such cellular responses. Recent studies have identified several transcription factors such as c-Jun, Fos and small Maf proteins that may play critical roles in the brain adaptation to hypercapnia. Hypercapnic stimulation also activates c-Jun NH2-terminal kinase (JNK) cascade via influx of extracellular Ca2+ through voltage-gated Ca2+ channels. In addition, several transmembrane proteins including Rhombex-29 (rhombencephalic expression protein-29 kDa) and Past-A (proton-associated sugar transporter-A) have been implicated in regulation of H+ sensitivity and brain acidosis-mediated energy metabolism, respectively. This review discusses current knowledge on the signalling mechanisms and molecular basis of neuronal adaptation during acidosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 17, Issue 7, July 2005, Pages 799-808
Journal: Cellular Signalling - Volume 17, Issue 7, July 2005, Pages 799-808
نویسندگان
Noriaki Shimokawa, Ivan Dikic, Shuei Sugama, Noriyuki Koibuchi,