Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining

► We examined hat mild hyperthermia inhibited homologous recombination repair. ► We examined translocation formation after hyperthermia. ► Inhibition of HR increased chromosomal translocation formation. ► Induction of chromosomal translocation is decreased by inhibition of NHEJ.