Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway

► Human NEIL3 mRNA levels, protein and DNA glycosylase activity is induced upon proliferative stimulation. ► Induction of hNEIL3 expression is under the control of the Ras dependent ERK-MAP kinase pathway. ► Human NEIL3 promoter contains characteristic promoter elements of cell cycle-regulated genes. ► mRNA expression pattern is different for hNEIL1, hNEIL2 and hNEIL3.