Polymerised placenta haemoglobin attenuates cold ischaemia/reperfusion injury in isolated rat heart

► Polymerised placenta haemoglobin (PolyPHb) attenuated cold ischaemia/ reperfusion injury. ► The PolyPHb regulated TLR2 and TLR4/NF-κB signalling pathway expression could, via restore the nitroso-redox balance. ► Our study provided a key link connecting inflammatory response, oxidative stress, innate immunity and hypoxia.