Evaluation of laser-speckle contrast image analysis techniques in the cortical microcirculation of piglets

► The cortical microcirculation was studied via closed cranial window in piglets. ► A novel laser-speckle image analysis (LASCA) technique was applied successfully. ► LASCA reveals perfusion changes matching previous quantitative data. ► LASCA appears to be more reliable than laser-Doppler flowmetry in piglets. ► Pial arterioles are major regulators of local blood flow in this neonatal model.