Substance P stimulates Growth Hormone (GH) and GH-Releasing Hormone (GHRH) secretions through tachykinin NK2 receptors in sheep

► Substance P stimulates GH and GHRH secretion in sheep. ► NK2 receptor antagonist blocks substance P-induced GH and GHRH release. ► NK1 receptor antagonist does not inhibit substance P-induced GH and GHRH release.