Effects of ghrelin on Cx43 regulation and electrical remodeling after myocardial infarction in rats

► Ghrelin showed the protective effect on ventricular arrhythmias after myocardial infarction in rats. ► Ghrelin drastically reduce the incidence of VT and prevent the loss of phosphorylated Cx43 during MI. ► Ghrelin may increase Cx43 expression in the infarcted heart through the inhibition of ET-1. ► Ghrelin can consider as a new strategy for the prevention of postinfarction ventricular arrhythmias.