Sulfoxaflor and the sulfoximine insecticides: Chemistry, mode of action and basis for efficacy on resistant insects

- Sulfoxaflor (SFX) is a sulfoximine insecticide with a distinct mode of action (MoA).
- SFX is not a neonicotinoid - different chemistry and structure activity relationships.
- SFX is highly active on neonicotinoid resistant insects.
- Differences in metabolism may explain the lack of cross-resistance for SFX.
- Aspects of SFX MoA may also factor in the lack of cross-resistance to neonicotinoids.