Attenuating effect of adenosine receptor agonists on the development of behavioral sensitization induced by sporadic treatment with morphine

► Intermittent treatment with morphine produced behavioral sensitization in mice. ► Adenosine receptor agonists inhibited morphine sensitization. ► A1 and A2A receptors are involved in morphine-induced sensitization. ► Adenosine agonists play a role in drug-seeking behavior and relapse to drug use.