Wnt interaction and extracellular release of prominin-1/CD133 in human malignant melanoma cells

► First report of release of prominin-1-containing microvesicles from cancer cells. ► Pro-metastatic role of prominin-1-containing microvesicles in FEMX-I melanoma. ► Down-regulation of prominin-1 results in decreased nuclear localization of β-catenin. ► Wnt signaling as mediator of the pro-metastatic activity of prominin-1.