Structural and numerical chromosome aberration inducers in liver micronucleus test in rats with partial hepatectomy

► Chromosome aberration inducers in rat liver micronucleus test are presented. ► Dosing before partial hepatectomy is necessary for structural aberration inducers. ► Dosing after partial hepatectomy is essential for numerical aberration inducers. ► Liver micronucleus induction in rats by colchicine occurred earlier than that in mice.