Insights into the failure of the potential, neutral myocardial imaging agent TcN-NOET: physicochemical identification of by-products and degradation species

Despite the identification of these “hydrolyzed” species, it is still unclear whether the failure to reach the clinical goal of the perfusion tracer [99mTc(N)(NOEt)2] is related to the degradation processes evidenced in this study or is the result of the mediocre imaging properties of the tracer.