A novel self-assembled nanoparticle vaccine with HIV-1 Tat49-57/HPV16 E749-57 fusion peptide and GM-CSF DNA elicits potent and prolonged CD8+ T cell-dependent anti-tumor immunity in mice

► We constructed nanoparticles Tat-E7/hGM-CSF and polyK-E7/hGM-CSF. ► PolyK-E7/hGM-CSF stimulates high anti-tumor immunity, but Tat-E7/hGM-CSF shows more efficiency than PolyK-E7/hGM-CSF. ► Tat-E7/hGM-CSF primes efficient CD8+ memory T cells response. ► This type of vaccine represents a promising novel peptide-based cervical cancer vaccines.