Protective efficacy of Mycobacterium indicus pranii against tuberculosis and underlying local lung immune responses in guinea pig model

► MIP provides long-term protection as compared to BCG against tuberculosis. ► Improved granulomatous immune response in MIP-group during chronic infection. ► Higher early protective Th1 immune response after M.tb infection in MIP-group. ► MIP-aerosol induced local lung as well as systemic protective immune response. ► MIP is safe and more effective in live form, causes no untoward reaction.