کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1097089 952828 2016 7 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
Interdisciplinary therapy improves cardiorespiratory fitness and inflammatory markers in obese adult women
ترجمه فارسی عنوان
درمان میان رشته ای، آمادگی قلبی تنفسی و شاخص‌های التهابی در زنان چاق بزرگسالان را بهبود می بخشد
کلمات کلیدی
سیتوکین؛ التهاب؛ تغییر در شیوه زندگی؛ چاقی؛ وزن، شاخص توده بدن؛ آمادگی قلبی عروقی، میانجی های شیمیایی پروتئین، فاکتور نکروز تومور ، حداکثر اکسیژن مصرفی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

IntroductionObesity is associated with an imbalance in cytokine concentrations, characterizing a low-grade chronic inflammatory status. The cardiorespiratory fitness is an important parameter that influences this inflammatory status, being a powerful predictor of early mortality. The interdisciplinary therapy has emerged as an alternative to prevent and treat obesity by improving health parameters. The aim of this study was to examine the effect of an interdisciplinary therapy on inflammatory markers and cardiorespiratory fitness in obese adult women.MethodsA total of twenty-eight (n = 28) adult women (age 43.3 ± 5.5 years and BMI 34.9 ± 3.1 kg/m2) completed 20 weeks of interdisciplinary therapy involving physical exercise, nutritional and psychological support at Obesity Study Group in Federal University of São Paulo, Santos – Brazil. The cardiorespiratory fitness was measured through a maximal cycle-ergometer test. The inflammatory markers analyzed were leptin, TNF-α, MCP-1 and adiponectin.ResultsImprovement in leptin (Δ −25.7% p < 0.001), MCP-1 (Δ −12.6% p < 0.001), relative VO2Max (Δ +15.4%, p = 0.001) and absolute VO2Max (Δ +10.8%, p = 0.001) were observed after the interdisciplinary therapy. In addition, a relevant negative correlation (r = −0.45, p = 0.021) was found between leptin level and cardiorespiratory fitness.ConclusionThe interdisciplinary therapy showed a significant positive effect on leptin and MCP-1 levels, cardiorespiratory fitness and metabolic profile. The therapy also showed an important negative correlation between leptin and cardiorespiratory fitness. These results suggest that the proposed methodology can be effective to treat obesity by increasing aerobic fitness and reducing proinflammatory pathways.Clinical Trial Registration NumberNCT02573688.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Obesity Medicine - Volume 2, June 2016, Pages 1–7
نویسندگان
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