کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10971692 | 1106509 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of CRTAM during mouse early T lymphocytes development
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کلمات کلیدی
VLA-4double negative thymocytesLFA1Double positive thymocytesZEBCADM1NKTEp-CAMHSAPDZICAM-1VCAMTECLymphocyte function-associated antigen-1 - آنتی ژن 1 مرتبط با عملکرد لنفوسیتHeat stable antigen - آنتی ژن پایدار گرماepithelia - اپیتلیاThymus - تیموسvery late antigen-4 - خیلی زود antigen-4Double negative - دو برابر منفی استDevelopment - رشدnatural killer T cell - سلول T قاتل طبیعیThymic epithelial cells - سلول های اپیتلیال Thymicepithelial cell adhesion molecule - مولکول چسبندگی سلولی اپیتلیالintercellular cell adhesion molecule-1 - مولکول چسبندگی سلولی سلول-1vascular cell adhesion molecule - مولکول چسبندگی سلولی عروقی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
CRTAM was reported as a novel receptor expressed in activated NKT and CD8 T lymphocytes. However, we have recently shown that it is also expressed in several non-immune tissues. In opposition to what has been stated for lymphoid cells, CRTAM expression is constitutive in epithelia, suggesting a role in cell-cell interactions. Given the importance of cell interactions during T lymphocyte development, we evaluated CRTAM during T lymphocyte ontogeny. Here we show that CRTAM has an unexpected constitutive expression in adult thymocytes and, remarkably, it is sustained during all stages of thymocyte development. CRTAM expression is restricted to CD8 and all DN subpopulations, with a consistent pattern from E13.5 stage to adult mice. Blocking CRTAM interaction with CADM1 impairs thymus growth, uncovering a novel role in thymus development, with a consequent impact in thymocyte maturation. Thus, CRTAM interaction with CADM1 is involved in structural maintenance of the thymic lobes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 34, Issue 2, February 2010, Pages 196-202
Journal: Developmental & Comparative Immunology - Volume 34, Issue 2, February 2010, Pages 196-202
نویسندگان
Oscar Medina-Contreras, Gloria Soldevila, Genaro Patiño-Lopez, Elsy Canche-Pool, Ricardo Valle-Rios, Vianney Ortiz-Navarrete,