Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor

► Breakthrough method for the scale-up of synchronous and asynchronous malaria blood stage cultures in wave bioreactor. ► Significant savings on both labour and material costs, and reduced likelihood of culture contamination. ► Method allows large scale isolation of various stages of intra-erythrocytic stages from single culture. ► Methods will allow high throughput screening of compound libraries using identical live parasites. ► Methods will allow development of live or dead cell vaccines under GMP compliant standards.