Effects of adenosine infusion on the minimum alveolar concentration of isoflurane in dogs

Although the MAC of isoflurane in dogs was not decreased significantly during infusion with adenosine (0.3 mg kg−1 minute−1), it was significantly decreased post-infusion, but only by 0.1 vol.%, an amount not considered clinically important. Adenosine infusion decreased mean arterial pressure by 27% and did not adversely affect renal function.