Sudden death in the presence of overt β-adrenergic receptor activation in guinea pigs immediately following isoflurane anesthesia

There was an increased rate of post-anesthetic mortality associated with isoproterenol pellet implantation in guinea pigs anesthetized with isoflurane compared to X/K. This may be due to the detrimental effects of the combination of isoflurane during overt β-adrenergic receptor activation or cardioprotective effects of X/K anesthesia during β-adrenergic receptor hyperactivity.