Clopidogrel Partially Counteracts Adenosine-5′-Diphosphate Effects on Blood Pressure and Renal Hemodynamics and Excretion in Rats

Our functional studies show that ADP can cause systemic and renal vasodilation and a decrease in mean arterial pressure, an action at least partly mediated by P2Y12 receptors. We confirmed that these receptors exert tonic action to reduce tubular water reabsorption and urine concentration.