کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11019599 | 1717629 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinical and imaging features distinguishing Susac syndrome from primary angiitis of the central nervous system
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Introduction: To assess clinical and/or imaging features useful to distinguish between Susac syndrome (SuS) and primary angiitis of central nervous system (PACNS). Methods: Multicenter retrospective analysis of two cohorts of Argentine patients diagnosed with SuS and PACNS. Results: 13 patients diagnosed with SuS (6 women and 7 men, mean age 35â¯Â±â¯10â¯years) and 15 with PACNS (10 women and 5 men, mean age 44â¯Â±â¯18â¯years) were analyzed. Cognitive impairment (11 out of 13 patients vs. 5 out of 15, pâ¯=â¯.006), ataxia (7 out of 13 vs. 2 out of 15, pâ¯=â¯.042) and auditory disturbances (7 out of 13 vs. 0 out of 15, pâ¯=â¯.003) were more frequent in SuS patients; whereas seizures were more frequent in PACNS patients (8 out of 15 vs. 1 out of 13, pâ¯=â¯.035). On MRI, corpus callosum (CC) involvement was observed more often in SuS, with abnormalities in CC genu, in 13 out of 13 SuS patients vs. only 2 out of 15 PACNS patients (pâ¯<â¯.001); in CC body these were present in 13 out of 13 SuS patients vs. 1 out of 15 PACNS patients, (pâ¯<â¯.001); and in CC splenium in 12 out of 13 Sus patients vs. 1 of 15 PACNS, pâ¯<â¯.001). Cortical lesions were more frequent in PACNS patients (10 out of 15 vs. 3 out of 13 SuS patients, pâ¯=â¯.02), as were hemorrhages (5 out of 15 vs. 0 out of 13 SuS, pâ¯=â¯.04) and multiple basal ganglia infarcts (7 out of 15 vs. 1 out of 13 Sus, pâ¯=â¯.037). Conclusion: Specific clinical and/or MRI findings may help distinguish SuS from PACNS with potential therapeutic implications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 395, 15 December 2018, Pages 29-34
Journal: Journal of the Neurological Sciences - Volume 395, 15 December 2018, Pages 29-34
نویسندگان
M. Marrodan, J.N. Acosta, L. Alessandro, V.C. Fernandez, E. Carnero Contentti, N. Arakaki, A.A. Kohler, M.P. Fiol, S.F. Ameriso, J. Correale,