کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11023052 | 1701347 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of dose and exposure protocol on the toxicokinetics and first-pass elimination of trichloroethylene and 1,1,1-trichloroethane
ترجمه فارسی عنوان
اثر پروتئین دوز و قرار گرفتن در معرض سم زدایی و حذف اولیه ترشیلاواتیلن و 1،1،1-تریکلوترن
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Trichloroethylene (TCE) and 1,1,1-trichloroethane (TRI) are frequent contaminants of drinking water and of groundwater at hazardous waste sites. There is relatively little information on the target organ deposition of TRI, despite its ingestion and common occurrence in humans. An important aim of the study was to delineate and contrast the toxicokinetics (TK) and bioavailability (F) of TRI and its well metabolized congener, TCE. Blood profiles were obtained from male Sprague-Dawley rats given aqueous emulsions of 6 or 48â¯mg TRI/kg and 10 or 50â¯mg TCE/kg as an oral bolus (po) or by gastric infusion (gi) over 2â¯h. TCE exhibited nonlinear TK, with a disproportionate increase in AUC and decrease in clearance and F with increase in dose. TRI exhibited linear TK. F did not vary significantly with TRI dose or dosage regimen. F values were substantially higher for TRI than for the respective TCE groups. TRI was distributed widely to tissues of rats gavaged with 6â¯mg TRI/kg, with accumulation in fat. This experiment yielded tissue uptake and elimination profiles and in vivo tissue:blood partition coefficients (PCs). Finally, additional rats were given 10â¯mg/kg of TCE and TRI po, ia and iv, so that first-pass hepatic (FPh) and pulmonary (FPp) elimination could be measured directly. Total and FPh elimination of TCE exceeded that of TRI. TRI, with its higher air:blood PC, exhibited the higher FPp. TCE and TRI, despite several common physical and chemical properties resulting in similar absorption and systemic distribution, displayed dissimilar dosage and dose rate effects on their TK.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 360, 1 December 2018, Pages 185-192
Journal: Toxicology and Applied Pharmacology - Volume 360, 1 December 2018, Pages 185-192
نویسندگان
Tanzir Mortuza, Srinivasa Muralidhara, Catherine A. White, Brian S. Cummings, Carey Hines, James V. Bruckner,