کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11033809 | 1568772 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Everolimus is a new anti-cancer molecule: Metabolic side effects as lipid disorders and hyperglycemia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
In the last few years, molecular targeted therapies have replaced traditional cytotoxic chemotherapy in the fight against many cancers to the extent that our understanding of tumor biology has become more sophisticated. This shift has markedly changed adverse event profiles, compared to cytotoxic chemotherapy, affecting a diverse range of organ systems. Everolimus was approved by the FDA in 2011 for the treatment of progressive pancreatic NE tumors. It is an inhibitor of mammalian target of rapamycin (mTOR) and exhibits antitumor activity via disruption of various signaling pathways and it's used in the treatment of advanced renal cell cancer, breast cancer and neuroendocrine tumors (NET); it's used also as anti-rejection agent for transplantation but with lower doses for anti-rejection (1.5-3.0â¯mg/day) than for anti-cancer (5-10â¯mg/day) treatment. Metabolic side effects are the most frequent reported and will be discussed in this review.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 143, September 2018, Pages 428-431
Journal: Diabetes Research and Clinical Practice - Volume 143, September 2018, Pages 428-431
نویسندگان
L. Morviducci, F. Rota, L. Rizza, P. Di Giacinto, S. Ramponi, M.R. Nardone, C. Tubili, A. Lenzi, P. Zuppi, R. Baldelli,