Four complement factor H gene polymorphisms in association with AMD: A meta-analysis

• To investigate the possible association between CFH gene polymorphisms and AMD risk.
• Four polymorphisms of CFH −543G > A, A473A, −257C > T, IVS15 were analyzed.
• Nineteen studies and 10,676 subjects were included in the present meta-analysis.
• A statistical significant association (P < 0.05) was observed in all four polymorphisms.
• A strong association still existed in −543G > A, A473A after stratified analysis for ethnicity

AimTo investigate the possible association between CFH gene polymorphisms −543G > A (rs1410996), A473A (rs2274700), −257C > T (rs3753394), IVS15 (rs1329428) and AMD risk.MethodsWe searched the published literature in the Medline and Scopus from inception to May 2015. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated in fixed or random effect model based on heterogeneity test among studies.ResultsNineteen studies with a total of 10,676 subjects were included in the present meta-analysis. A statistical significant association was observed between AMD risk and CFH −543G > A polymorphism with OR of 1.77 (95% CI, 1.47–2.12), 2.24 (95% CI, 1.71–2.94), 0.49 (95% CI, 0.38–0.62) and 0.25 (95% CI, 0.18–0.37) in additive, dominant, recessive and codominant models, respectively. Similar results were obtained in polymorphisms A473A, −257C > T, IVS15. Furthermore, stratified analysis for ethnicity showed a significantly strong association between −543G > A, A473A polymorphisms and AMD risk.ConclusionThe present meta-analysis suggested that CFH −543G > A, A473A, −257C > T, and IVS15 polymorphisms might be moderately associated with AMD risk. This conclusion warrants confirmation by further studies.