Intragastric nitration by dietary nitrite: Implications for modulation of protein and lipid signaling

► Nitrite from dietary products yields nitrating species in the acidic gastric lumen. ► Specific gastric protein mediators are targets for nitrite-derived nitrating agents. ► Gastric-nitrated lipids might exert local and systemic functions, upon absorption. ► Intragastric protein and lipid nitration may occur in vivo with functional impact.