کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1913046 1535100 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optic neuritis with positive HLA-B27: Characteristic phenotype in the Chinese population
ترجمه فارسی عنوان
Neuritis اپتیک با HLA-B27 مثبت: فنوتیپ مشخص در جمعیت چینی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• HLA-B27-positive optic neuritis (ON) may present recurrent episodes and severe visual impairment at onset.
• Bilateral sacroiliitis are frequent in HLA-B27-positive ON.
• This study exhibited the largest body of clinical data for HLA-B27-positive ON.

PurposeThis study retrospectively reviewed the clinical features of optic neuritis (ON) with positive HLA-B27.MethodClinical data were reviewed for HLA-B27-positive ON in the Chinese People's Liberation Army General Hospital from January 2009 through June 2015. The prevalence of HLA-B27 and spondyloarthropathies was analyzed. Clinical features of HLA-B27-positive ON based on serum aquaporin 4-antibody (AQP4-Ab) were compared.ResultsA total of 22 ON patients (14 female/8 male, 38 involved eyes) with positive HLA-B27 were collected from 410 ON patients. Recurrent episodes were observed in 14/22 patients, and seven patients presented as bilateral simultaneous ON. A total of 68.4% (22/38) of involved eyes exhibited severe visual impairment (< 0.1) at onset. A total of 8/22 patients were seropositive for AQP4-Ab, and clinical features did not differ based on AQP4-Ab status. Bilateral sacroiliitis was revealed in over 50% (7/13) of patients screened using pelvic computed tomography. Three patients were diagnosed with ankylosing spondylitis (AS), and one patient experienced co-occurrence of active AS and bilateral ON.ConclusionsHLA-B27-positive ON may presented recurrent episodes and severe visual impairment at onset. The co-occurrence of ON and AS, and the frequent presence of bilateral sacroiliitis may indicate an underlying alternation of autoimmune background in this condition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 362, 15 March 2016, Pages 100–105
نویسندگان
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