کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1920470 1535827 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced after-effects following podokinetic adaptation in people with Parkinson's disease and freezing of gait
ترجمه فارسی عنوان
پس از اثرات کاهشی پس از انطباق podokinetic در افراد مبتلا به بیماری پارکینسون و انجماد راه رفتن
کلمات کلیدی
بیماری پارکینسون؛ انجماد راه رفتن، سازگاری حرکتی؛ پس از اثرات
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• We compared after-effects following locomotor adaptation in Parkinson's disease.
• Participants with and without freezing of gait were included.
• Magnitude of after-effects were smaller in the freezer group.
• After-effects were similar between controls and the non-freezer group.
• People who freeze may have less storage of adapted locomotor patterns.

IntroductionGait dysfunction is common in people with Parkinson's disease (PD). Freezing of gait (FOG) is one such gait disturbance that significantly impacts mobility and quality of life in PD. Recent evidence suggests that cerebellar connectivity may differ in people with PD and FOG (PD+FOG) relative to those without FOG (PD-FOG). Investigation of gait adaptation, or the ability to change gait patterns in response to external perturbations, is cerebellum-dependent, is a practical means of probing cerebellar integrity and may provide additional insights regarding the FOG phenomenon.MethodsIn this study, we investigated gait adaptation in PD and FOG by measuring after-effects, namely whole-body rotation, following stepping on a rotating disc in PD+FOG compared to PD-FOG and older healthy adults. We refer to the period of stepping on the rotating disc as the podokinetic (PK) stimulation and after-effects as podokinetic after-rotation (PKAR). Our primary measure of adaptation was the magnitude and rate of decay of the after-effects.ResultsWe noted that PKAR was diminished in PD+FOG compared to the other groups, indicating reduced storage of the adapted gait pattern in PD+FOG. In the PD groups, FOG explained about 20% of the variability in peak velocity. Furthermore, these differences were independent of stepping cadence or motor sign severity.ConclusionOur results show that gait adaptation is impaired in PD+FOG, suggesting the cerebellum may be differentially impacted in PD+FOG compared to PD-FOG. This supports previous neuroimaging evidence of cerebellar dysfunction in PD+FOG. Overall, these data further our understanding of gait deficits in PD+FOG.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 22, January 2016, Pages 93–97
نویسندگان
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