کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1922799 1535841 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of high and low dose ionising radiation on the central nervous system
ترجمه فارسی عنوان
تاثیر تابش یونیزاسیون با دوز بالا و پایین در سیستم عصبی مرکزی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Ionising radiation can modulate responses of microglial cells in the CNS.
• High doses can induce ROS formation, oxidative stress and neuroinflammation.
• Low doses can mitigate tissue damage via antioxidant defences.
• TSPO as a potential biomarker and modulator of radiation induced effects in the CNS.
• Non-linear differential microglial activation to high and low doses is proposed.

Responses of the central nervous system (CNS) to stressors and injuries, such as ionising radiation, are modulated by the concomitant responses of the brains innate immune effector cells, microglia. Exposure to high doses of ionising radiation in brain tissue leads to the expression and release of biochemical mediators of ‘neuroinflammation’, such as pro-inflammatory cytokines and reactive oxygen species (ROS), leading to tissue destruction. Contrastingly, low dose ionising radiation may reduce vulnerability to subsequent exposure of ionising radiation, largely through the stimulation of adaptive responses, such as antioxidant defences. These disparate responses may be reflective of non-linear differential microglial activation at low and high doses, manifesting as an anti-inflammatory or pro-inflammatory functional state. Biomarkers of pathology in the brain, such as the mitochondrial Translocator Protein 18 kDa (TSPO), have facilitated in vivo characterisation of microglial activation and ‘neuroinflammation’ in many pathological states of the CNS, though the exact function of TSPO in these responses remains elusive. Based on the known responsiveness of TSPO expression to a wide range of noxious stimuli, we discuss TSPO as a potential biomarker of radiation-induced effects.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Redox Biology - Volume 9, October 2016, Pages 144–156
نویسندگان
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