کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1941670 1536902 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glypican-5 is a tumor suppressor in non-small cell lung cancer cells
ترجمه فارسی عنوان
Glypican-5 یک سرکوب کننده تومور در سلول های سرطانی ریه سلول غیرکوچک است
کلمات کلیدی
Glypican-5؛ سیگنالینگ سلول ؛ سرکوبگر تومور. سرطان ریه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• GPC5 suppresses anchorage-independent growth of lung cancer cells.
• GPC5 suppresses xenograft growth of lung cancer cells.
• GPC5 is localized to the membrane and suppresses oncogenic RTKs.

Glypican-5 (GPC5) belongs to the glypican family of proteoglycans that have been implicated in a variety of physiological processes, ranging from cell proliferation to morphogenesis. However, the role of GPC5 in human cancer remains poorly understood. We report that knockdown of GPC5 in bronchial epithelial cells promoted, and forced expression of GPC5 in non-small lung cancer (NSCLC) cells suppressed, the anchorage-independent cell growth. In vivo, expression of GPC5 inhibited xenograft tumor growth of NSCLC cells. Furthermore, we found that GPC5 was expressed predominantly as a membrane protein, and its expression led to diminished phosphorylation of several oncogenic receptor tyrosine kinases, including the ERBB family members ERBB2 and ERBB3, which play critical roles in lung tumorigenesis. Collectively, our results suggest that GPC5 may act as a tumor suppressor, and reagents that activate GPC5 may be useful for treating NSCLC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemistry and Biophysics Reports - Volume 6, July 2016, Pages 108–112
نویسندگان
, , , ,