کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1941700 1536903 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TNF induced inhibition of Cirbp expression depends on RelB NF-κB signalling pathway
ترجمه فارسی عنوان
مهار ناشی از TNF بیان Cirbp بستگی به مسیر سیگنالینگ RelB NF-kB
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• TNF effect on Cirbp expression is inhibited by blocking IKKα or IKKβ.
• Knockdown of RelB prevents TNF dependent Cirbp repression.
• Non-canonical NF-κB pathway seems to regulate Cirbp expression in inflammation.

The circadian clock is required for the rhythmic expression of a plethora of genes that orchestrate metabolism, sleep-wake behaviour and the immune response to pathogens. The cold-inducible RNA binding protein (CIRBP) is required for high amplitude expression of clock genes. Moreover, CIRBP protects the expression of clock genes from the inhibitory effects of tumour necrosis factor (TNF). However, since TNF represses Cirbp expression, the protective effect of CIRBP is lost. Here, we show that the TNF effect on Cirbp requires the non-canonical NF-κB signalling pathway. While a knock down of RelA does not alter the effects of TNF on Cirbp, a knock down of RelB represses this effect. In addition, the data indicate that p50 and p52 are required in the TNF induced inhibition of Cirbp. These results show that Cirbp expression in TNF treated cells is regulated via the non-canonical NF-κB pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemistry and Biophysics Reports - Volume 5, March 2016, Pages 22–26
نویسندگان
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