Massive translational repression of gene expression during mouse erythroid differentiation

►Identification of six clusters of genes strictly translationally regulated ►Control of mRNA expression and translation efficiency display distinct characteristics ►Translational control affects gene expression differentially in terms of kinetics, response intensity and class of genes also affected transcriptional regulation ►Translational control affects a smaller fraction of genes but was effective at earlier time-points as regulation on a transcriptional level ►56% of all the regulated genes by a factor of three are exclusively controlled by mRNA expression, whereas 16% of them are submitted solely to translational regulation and 28% are regulated by both mechanisms