کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1946782 | 1054270 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Linker histone subtypes are not generalized gene repressors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
âºAntibodies to the six chicken histone H1 subtypes and the variant histone H5 have been used in xChIPs to map their distribution across the β-globin locus in three cell types: 15-day embryo chicken erythrocytes, 15-day embryo chicken brain and the early erythroid cell line HD24. âºIn erythrocytes, the H1.01, H1.11L and H1.11R subtypes are substantially depleted throughout the β-globin locus and the neighboring heterochromatin. âºIn HD24 cells substantial depletions are found at the promoters of the adult βA and embryonic Î²Ï and βε genes, despite these genes not yet being active in these cells. âºThe distributions in brain tissue are characterised by the absence of H1.02, H1.03 and H5 from the hypersensitive site HS3 and from the β-adult 3â² enhancer for the H1.11L and H1.11R subtypes. âºActive genes therefore carry high levels of some but not all linker histone subtypes. âºLinker histone subtypes play distinct cell-type specific roles in gene regulation, their widespread distribution indicates they are not intrinsically inhibitory to basic chromatin transactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1799, Issue 9, September 2010, Pages 642-652
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1799, Issue 9, September 2010, Pages 642-652
نویسندگان
Alexandra F. Trollope, Nelly Sapojnikova, Alan W. Thorne, Colyn Crane-Robinson, Fiona A. Myers,