کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1959589 | 1057941 | 2005 | 6 صفحه PDF | دانلود رایگان |
The toxin α-hemolysin expressed by uropathogenic Escherichia coli bacteria was recently shown as the first pathophysiologically relevant protein to induce oscillations of the intracellular Ca2+ concentration in target cells. Here, we propose a generic three-variable kinetic model describing the Ca2+ oscillations induced in single rat renal epithelial cells by this toxin. Specifically, we take into account the interplay between 1), the cytosolic Ca2+ concentration; 2), IP3-sensitive Ca2+ channels located in the membrane separating the cytosol and endoplasmic reticulum; and 3), toxin-related activation of production of IP3 by phospholipase C. With these ingredients, the predicted response of cells exposed to the toxin is in good agreement with the results of experiments.
Journal: - Volume 88, Issue 4, April 2005, Pages 2976–2981