کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965091 1538641 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lactate dehydrogenase in sickle cell disease
ترجمه فارسی عنوان
لاکتات دهیدروژناز در بیماری سلول داسی شکل
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Lactate dehydrogenase is a marker of intravascular hemolysis in SCD associated with vascular damage.
• During acute vaso-occlusive crisis, LDH has been correlated with the severity of pain and clinical state worsening.
• Very high LDH activity during acute painful vaso-occlusive crisis should suggest specific life-threatening complications.
• Elevated LDH activity at steady-state is a predicting component of the “hyper hemolytic phenotype”.
• A decline of LDH level during hydroxyurea therapy is associated with better survival.

Lactate dehydrogenase (LDH) activity is elevated in many pathological states. Interest in LDH activity in sickle cell disease (SCD) has developed out of an increased comprehension of the pathophysiological process and the clinical course of the disease. Elevated LDH activity in SCD comes from various mechanisms, especially intravascular hemolysis, as well as ischemia-reperfusion damage and tissular necrosis. Intravascular hemolysis is associated with vasoconstriction, platelet activation, endothelial damage, and vascular complications. LDH has been used as a diagnostic and prognostic factor of acute and chronic complications. In this review we have evaluated the literature where LDH activity was examined during steady-state or acute conditions in SCD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 458, 1 July 2016, Pages 99–102
نویسندگان
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