کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1968539 1538862 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum activin B concentration as predictive biomarker for ectopic pregnancy
ترجمه فارسی عنوان
غلظت سرمی activin B به عنوان نشانگر پیشگویانه برای بارداری خارج از رحم
کلمات کلیدی
حاملگی خارج رحمی؛ سقط جنین داخل رحمی؛ Activin B؛ دقت تشخیصی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Serum activin B concentration is low tEP and IUM compared to normal IUP.
• When compared between tEP and IUM, activin B concentrations do not differ significantly.
• Serum activin B concentration can discriminate tEP from normal pregnancy with moderate accuracy.
• It also shows improved diagnostic potential along with β-hCG, but cannot distinguish tEP from IUM reliably.

We evaluated the diagnostic accuracy of activin B in discriminating tubal ectopic pregnancy (tEP) from intrauterine miscarriages (IUM), and normal viable intrauterine pregnancy (IUP). We included 28 women with tEP, 31 women with IUM, and 29 normal IUP, confirmed both by clinical examination and ultrasonography. Serum activin B concentration was measured at the time of admission using the ELISA kit. The median serum activin B concentration was found to be significantly decreased in both tEP (p = 0.004) and IUM (p = 0.022) compared to normal IUP. When compared between tEP and IUM, activin B concentrations did not differ significantly. ROC analysis of activin B and free β-hCG demonstrated AUC of 0.722 and 0.805, respectively to discriminate tEP from viable IUP. The model including both activin B and free β-hCG improved the discriminating potential with greater AUC (0.824), and specificity (93%) than individual one. To discriminate tEP from IUM, activin B, free β-hCG and combination of both performed poorly. We conclude that serum activin B concentration is lower in tubal ectopic pregnancy, and can discriminate it from normal pregnancy with moderate accuracy. It also shows improved diagnostic potential along with free β-hCG, but cannot distinguish tEP from IUM reliably.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 49, Issues 7–8, May 2016, Pages 609–612
نویسندگان
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