Filamin-A as a marker and target for DNA damage based cancer therapy

► Down-regulation of filamin-A impairs DNA repair efficiency. ► Filamin-A expression level reversely correlates with drug sensitivity. ► Inhibition of filamin-A sensitizes melanoma xenografts to treatment. ► Filamin-A is a cytoskeleton protein that supports DNA repair. ► Filamin-A may be used as a biomarker and target for DNA damage based cancer therapy.