Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells

These results allow us to conclude that activation/high expression of PKC-α protects parental drug-sensitive L1210 cells from iHDACs-mediated apoptosis. Thus, determination of PKC-α levels/activity in leukaemia seems to be relevant when choosing efficient chemotherapy protocols based on the use of apoptosis-inducing anticancer drugs.