کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1991402 1541002 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Membrane-mediated actions of 1,25-dihydroxy vitamin D3: A review of the roles of phospholipase A2 activating protein and Ca2+/calmodulin-dependent protein kinase II
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Membrane-mediated actions of 1,25-dihydroxy vitamin D3: A review of the roles of phospholipase A2 activating protein and Ca2+/calmodulin-dependent protein kinase II
چکیده انگلیسی


• Silencing Camk2a inhibits 1α,25(OH)2D3-stimulated PLA2 and PKC activation.
• Silencing PLAA inhibits 1α,25(OH)2D3-stimulated CaMKII, PLA2 and PKC activation.
• 1α,25(OH)2D3 membrane signaling acts via rapid activation of PLAA.
• PLAA activates CaMKII, PLA2 and PKC, arachidonic acid release and PGE2 production.

The secosteroid 1α,25-dihydroxy vitamin D3 [1α,25(OH)2D3] acts on cells via classical steroid hormone receptor-mediated gene transcription and by initiating rapid membrane-mediated signaling pathways. In its membrane-initiated pathway, after 1α,25(OH)2D3 interacts with protein disulfide isomerase, family A, member 3 (Pdia3) in caveolae, phospholipase A2 (PLA2) and protein kinase C (PKC) are activated. Recent efforts to determine the signaling proteins involved in the 1α,25(OH)2D3 signal from Pdia3 to PLA2 have indicated that phospholipase A2 activating protein (PLAA) and Ca2+/calmodulin-dependent kinase II (CaMKII) are required. PLAA is located in caveolae, where it interacts with Pdia3 and caveolin-1 (Cav-1) to initiate rapid signaling via CaMKII, activating PLA2, leading to activation of protein kinase C (PKC) and PKC-dependent responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 147, March 2015, Pages 81–84
نویسندگان
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