کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1993182 1541224 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Minimum dominating set-based methods for analyzing biological networks
ترجمه فارسی عنوان
حداقل روشهای مبتنی بر مجموعه مبتنی بر تحلیل شبکه های بیولوژیکی
کلمات کلیدی
حداقل مجموعه حاکم، شبکه های پیچیده شبکه های متقابل پروتئین-پروتئین، قابلیت کنترل شبکه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• The fast increase of ‘multi-omics’ data requires novel algorithmic methodologies.
• The minimum dominating set (MDS) approach is a promising method to analyse biological networks.
• The key methodologies and algorithms are examined from proteomics and transcriptomics to metabolomics.

The fast increase of ‘multi-omics’ data does not only pose a computational challenge for its analysis but also requires novel algorithmic methodologies to identify complex biological patterns and decipher the ultimate roots of human disorders. To that end, the massive integration of omics data with disease phenotypes is offering a new window into the cell functionality. The minimum dominating set (MDS) approach has rapidly emerged as a promising algorithmic method to analyze complex biological networks integrated with human disorders, which can be composed of a variety of omics data, from proteomics and transcriptomics to metabolomics. Here we review the main theoretical foundations of the methodology and the key algorithms, and examine the recent applications in which biological systems are analyzed by using the MDS approach.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 102, 1 June 2016, Pages 57–63
نویسندگان
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