Transplantation of endothelial progenitor cells overexpressing endothelial nitric oxide synthase enhances inhibition of neointimal hyperplasia and restores endothelium-dependent vasodilatation

►eNOS transfection enhances the proliferation and NO production of EPC. ►EPC transplantation reduces neointimal hyperplasia and resumes EDVD function. ►eNOS transfection further enhances the vasculoprotective effect of EPC transplantation.