کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1995519 | 1541301 | 2007 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potential therapeutic strategies for lymphatic metastasis
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کلمات کلیدی
HGFFGFRPDGFFGF-2IL-8COX-2VECVEGF-CVEGFR-3NRPSema3FLECIGFVEGFREGFPDGFRiGFR - IGFRAngiopoietins - آنژیوپوتیین هاAngiogenesis - آنژیوژنزAng - اینInterleukin-8 - اینترلوکین -8vascular endothelial cell - سلول اندوتلیال عروقیLymphatic endothelial cell - سلول اندوتلیال لنفاویCyclooxygenase-2 - سیکلوکوکسیژناز2epidermal growth factor - عامل رشد اپیدرمیHepatocyte growth factor - عامل رشد هپاتوسیتVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)platelet-derived growth factor - فاکتور رشد حاصل از پلاکتInsulin-like growth factor - فاکتور رشد مانند انسولینLymphangiogenesis - لنفانژیوژنزMetastasis - متاستاز Inhibitors - مهارکنندهNeuropilin - نوروپیلینplatelet-derived growth factor receptor - گیرنده عامل فاکتور رشد یافته پلاکتvascular endothelial growth factor receptor - گیرنده فاکتور رشد اندوتلیال عروقیfibroblast growth factor receptor - گیرنده فاکتور رشد فیبروبلاستInsulin-like growth factor receptor - گیرنده فاکتور رشد مانند انسولین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Physiologically, the lymphatic system regulates fluid volume in the interstitium and provides a conduit for immune cells to travel to lymph nodes, but pathologically, the lymphatic system serves as a primary escape route for cancer cells. Lymphatic capillaries have a thin discontinuous basement membrane, lack pericyte coverage and often contain endothelial cell gaps that can be invaded by immune cells (or tumor cells). In addition, tumor cells and stromal cells in the tumor microenvironment secrete factors that stimulate lymphangiogenesis, the growth of lymphatic endothelial cells and the sprouting of lymphatic capillaries. As a result, many tumors are surrounded by large, hyperplastic, peri-tumoral lymphatic vessels and less frequently are invaded by intra-tumoral lymphatic vessels. Carcinoma cells commonly metastasize through these lymphatic vessels to regional lymph nodes. The presence of metastatic cells in the sentinel lymph node is a prognostic indicator for many types of cancer, and the degree of dissemination determines the therapeutic course of action. Lymphangiogenesis is currently at the frontier of metastasis research. Recent strides in this field have uncovered numerous signaling pathways specific for lymphatic endothelial cells and vascular endothelial cells. This review will provide an overview of tumor lymphangiogenesis and current strategies aimed at inhibiting lymphatic metastasis. Novel therapeutic approaches that target the tumor cells as well as the vascular and lymphatic endothelial compartments are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 74, Issues 2â3, SeptemberâNovember 2007, Pages 145-158
Journal: Microvascular Research - Volume 74, Issues 2â3, SeptemberâNovember 2007, Pages 145-158
نویسندگان
Bernadette M.M. Zwaans, Diane R. Bielenberg,