کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2010446 1066977 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacology and metabolism of infliximab biosimilars – A new treatment option in inflammatory bowel diseases
ترجمه فارسی عنوان
فارماکولوژی و متابولیسم مشابهت زیستی اینفیلیکسیماب - یک گزینه درمانی جدید در بیماری های التهابی روده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

Biological therapy with monoclonal antibodies to tumor necrosis factor alpha (TNF-α) was shown in large clinical trials to be effective in inducing and maintaining clinical remission in patients with moderate to severe Crohn's disease (CD) and ulcerative colitis (UC). Infliximab, the first anti-TNF-α biologic drug, has significantly improved inflammatory bowel disease (IBD) treatment outcomes by preventing structural damage progression, thereby reducing complications and the need for surgery and hospitalization. The major concern associated with the use of biologics is their high cost. However, as these therapies lose patent protection, cheaper biosimilar versions of the originator products are being developed, such as the infliximab biosimilar CT-P13. Position statements from several scientific societies and some experts in their reviews have expressed concerns to the concept of extrapolation without direct IBD clinical evidence, whereas European Medicines Agency (EMA) experts have supported extrapolation.In this review, we focus on the pharmacokinetics, pharmacodynamics properties and comparative effectiveness of anti-TNF-α biosimilars, related to their use in IBD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 68, Issue 4, August 2016, Pages 797–801
نویسندگان
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