کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2012058 | 1067023 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nefopam enhances the protective activity of antiepileptics against maximal electroshockinduced convulsions in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Nefopam enhances the protective activity of antiepileptics against maximal electroshockinduced convulsions in mice Nefopam enhances the protective activity of antiepileptics against maximal electroshockinduced convulsions in mice](/preview/png/2012058.png)
چکیده انگلیسی
Nefopam is a centrally acting non-opioid analgesic with a mechanism of action that is not completely understood. Adverse effects associated with the therapeutic use and overdose of nefopam are mainly associated with the central nervous system, such as hallucinations, cerebral edema and convulsions. The aim of this study was to assess the effect of nefopam on the electrical threshold and its influence on the protective activity of antiepileptic drugs in the maximal electroshock test in mice. A 5Â mg/kg dose of nefopam sig-nificantly elevated the electric seizure threshold, while a dose of 1Â mg/kg failed to protect mice against electroconvulsion. At a subthreshold dose of 1Â mg/kg, nefopam significantly enhanced the anticonvulsant activity of valproate against electroconvulsions. The protective activity of phenobarbital and phenytoin was significantly enhanced by co-administration of nefopam at the 5Â mg/kg dose, but this same dose of nefopam failed to affect the protective activity of carbamazepine. In conclusion, nefopam exerts an anticonvulsive effect when given alone and significantly enhances the protective activity of certain antiepileptic agents against electroconvulsions induced in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 63, Issue 3, MayâJune 2011, Pages 690-696
Journal: Pharmacological Reports - Volume 63, Issue 3, MayâJune 2011, Pages 690-696
نویسندگان
MirosÅaw Czuczwar, Katarzyna Czuczwar, Jacek CiÄszczyk, Jacek KiÅ, Tomasz Saran, Jarogniew J. Åuszczki, Waldemar A. Turski,